POSNOC is a large clinical trial exploring new treatments for breast cancer

Positive sentinel node: adjuvant therapy alone versus adjuvant therapy plus clearance or axillary radiotherapy.


POSNOC is a 10 year clinical study looking at the armpit treatment provided to women diagnosed with early stage breast cancer. It will involve more than 50 hospitals and 1900 women across the UK.

For women with early breast cancer undergoing surgery, the surgeon removes one or two lymph glands from the armpit on the side of the cancer to check if the cancer has spread to the lymph glands. For about a quarter of women, the breast cancer has spread to the lymph glands. Currently, these women undergo further treatment to their armpit (axillary treatment). This is either a second operation to remove all the lymph glands in the armpit or radiotherapy to the armpit.


Further armpit treatment is the focus of this study as it can carry risks and potential side effects. Symptoms can include:

swelling in the arm and shoulder

  • pain
  • numbness
  • impairment of the arm
  • shoulder stiffness


The aim of the study is to find out if armpit treatment is of benefit in women with cancer spread to one or two lymph glands, receiving one or more of drug treatments (chemotherapy or endocrine therapy).



AllTrials logo


VOICE 2016

A snapsot video of the the 2016 course is now available on YouTube VOICE2016

eCancer Videos

At the BACR/ECMC conference in July Maggie Wilcox and Mairead Mackenzie were persuaded to speak to the camera. Maggie gave a background to ICPV and our aims and objectives. While Mairead focused on her specific interests and activities. To view follow the links below.

Maggie Wilcox

Mairead MacKenzie

July 2016 Conferences

ICPV members were busy this week with two conferences. The BACR/ECMC Joint Meeting on Therapeutic Interventions for Cancer Prevention was held in Bristol July18-19. The UK Breast Cancer Research Symposium was held in London from July 22-23. Click here for more information.

UK Therapeutic Cancer Prevention Network (UKTCPN)

An update from this new group was presented to the ECMC Annual Network Meeting in May 2016. Click here to download and read. 

Voice 2016

The ICPV Science for Advocates Course will be hosted by Warwick CTU from 19th - 23rd September. See the VOICE pages for more information.

The Voice, Winter 2015-2016

The latest ICPV newsletter is now available. It has reviews of members activities, meeting attended and papers published. Go to the ICPV Publications page to download.


Call for immediate change to European Paediatric Medicine Regulation to save more lives of children and teens with cancer.
A few basic changes to European Law could speed up access to newer, kinder and potentially better drugs for more children and teenagers with cancer. Click to Sign the petition 


Two years on from the start pioneering TRACERx lung cancer study. Click here For the latest news and patient views on this study. 

NCRI Conference 2015, Liverpool

ICPV members will be joining cancer researchers from 1-4 Nov, 2015. Click here for more information.

ICPV Summer School 2015

Qualitative Research Training Course at Warwick. Click here for a review of the session.

NCIN, Belfast, June 2015

Several ICPV members attended and spoke at this years conference. Click here for more.

AACR Conference, Philadelphia, April 2015

ICPV Member Pat Fairbrother joined US advocates at this year's conference. Read her review of the event here.

Cancer Drugs Fund

Today (19 Jan 2015) The Telegraph has published a letter from ICPV & fourteen other charities on the current CDF situation. Go to our Facebook or Twitter page for Telelgraph weblink or click below for the letter.

Letter to Telegraph.pdf
Adobe Acrobat document [809.6 KB]

Contact us by email



Or use our online contact form